Progress in deciphering trophoblast cell differentiation during human placentation
نویسندگان
چکیده
منابع مشابه
Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation.
BACKGROUND In primate placenta, extravillous trophoblast (EVT) invades maternal tissue in temporally- and spatially-regulated fashions. We previously identified a novel placenta-specific cell-surface aminopeptidase, laeverin/aminopeptidase Q, which is expressed on EVT-lineage cells in the fetal membrane. Laeverin possesses a peptide-binding site that is evolutionally unique to primates, suggest...
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The genetic program that directs human placental differentiation is poorly understood. In a recent study, we used DNA microarray analyses to determine genes that are dynamically regulated during human placental development in an in vitro model system in which highly purified cytotrophoblast cells aggregate spontaneously and fuse to form a multinucleated syncytium that expresses placental lactog...
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The process of implantation and placentation in women in volves a series of intercellular interactions, the eventual elucidation of which will result in extensions or even shifts of cell biological paradigms. These include the formation of motile and non-motile mononuclear and multinuclear trophoblast, alterations between faster and slower states of proliferation, changes in adhesive properties...
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Based on the number of tissues separating maternal from fetal blood, placentas are classified as epitheliochorial, endotheliochorial or hemochorial. We review the occurrence of these placental types in the various orders of eutherian mammals within the framework of the four superorders identified by the techniques of molecular phylogenetics. The superorder Afrotheria diversified in ancient Afri...
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Epidemiological data suggest an association between exposures to bromodichloromethane (BDCM), a trihalomethane found in drinking water as a result of drinking water disinfection, and an increased risk of spontaneous abortion. We previously hypothesized that BDCM targets the placenta and showed that the secretion of chorionic gonadotrophin (CG) was reduced in primary cultures of human term syncy...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2020
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2020.08.010